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International Symposium of Public Health and International Conference of Epidemiology Public Health

THE IMPACT OF REPEAT ADMISSIONS ON DRUG-DRUG INTERACTION RISK IN HEART FAILURE PATIENTS

Date Published : 15 September 2026

Contributors

Ratih Puspita Febrinasari

Universitas Sebelas Maret
Author

Benedictus

Universitas Sebelas Maret
Author

Keywords

drug interactions heart failure medication safety polypharmacy hospitalization

Proceeding

(2026): PROCEEDING OF 9th INTERNATIONAL SYMPOSIUM OF PUBLIC HEALTH (ISOPH)

Track

General Track

License

Copyright (c) 2026 International Symposium of Public Health and International Conference of Epidemiology Public Health

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Abstract

Background: Drug-drug interactions (DDIs) pose a significant risk to hospitalized patients, particularly those with heart failure who often have complex medication regimens. . However, it remains unclear how this interaction risk profile—specifically its frequency and severity—evolves with recurrent hospitalizations. Therefore, this study aimed to determine the occurrence and characteristics of potential DDIs, focusing on changes in their frequency and severity across multiple admissions. Method: This retrospective observational study analyzed data from the electronic medical records of 332 heart failure patients who had 494 hospitalizations between 2022 and 2023 at Universitas Sebelas Maret Teaching Hospital. The study aimed to determine the occurrence and characteristics of potential DDIs, focusing on changes in their frequency and severity across multiple admissions. Result: A total of 7,562 potential DDIs were identified. The majority (81.4%) were classified as "Monitor Closely," while "Serious" interactions accounted for 8.0%. The overall frequency of DDIs remained stable across subsequent hospitalizations. Critically, the number of serious drug interactions showed a statistically significant decrease with each successive admission. The most frequent "Serious" interaction was between aspirin and captopril. Conclusion: Potential DDIs are highly prevalent in hospitalized heart failure patients, but their overall frequency does not increase with repeat hospitalizations. The significant reduction in serious DDIs with subsequent admissions suggests that current clinical safety systems and interventions are effective at progressively mitigating the most dangerous medication-related risks over time.

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How to Cite

Febrinasari, R. P., & Benedictus, B. (2026). THE IMPACT OF REPEAT ADMISSIONS ON DRUG-DRUG INTERACTION RISK IN HEART FAILURE PATIENTS. International Symposium of Public Health and International Conference of Epidemiology Public Health, 49-56. https://e-conference.unair.ac.id/isoph/paper/view/1564